研究業績

1.学術論文

Ikuta, R. and Hamada, S. The presynaptic active zone protein Bassoon as a marker for synapses between Type III cells and afferent nerve fibers in taste buds?Chem Senses 47 bjac016, 2022

Okumura F., Oki N., Fujiki Y, Ikuta R., Osaki ,K., Hamada, s., Nakatsukasa K., Hisamoto N., Hara T., Kamura T. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation Scientific reports 11(1) DOI: 10.1038/s41598-021-00306-6, 2021

Ikuta R, Myoenzono K, Wasano J, Hamaguchi-Hamada K, Hamada S, Kurumata-Shigeto M. N-cadherin localization in taste buds of mouse circumvallate papillae. J Comp. Neurol. 529(9):2227-2242. doi: 10.1002/cne.25090, 2021

Okamoto, S., Esumi, S., Hamaguchi-Hamada, K., Hamada, S.(2018)?β-methylamino-L-alanine (BMAA) suppresses cell cycle progression of non-neuronal cell?Scientific reports, 8, Article number: 17995, 2018

Hamaguchi-Hamada, K., Kurumata-Shigeto, M., Minobe, S., Fukuoka, N., Sato, M., Matsufuji, M., Koizumi, O., Hamada, S. Thrombospondin Type-1 Repeat Domain-containing Proteins are Strongly Expressed in the Head Region of Hydra. PLoS ONE, 11(4), e0151823, doi:10.1371/journal.pone.0151823, 2016

Kaneko R, Sato A, Hamada S, Yagi T, Ohsawa I, Ohtsuki M, Kobayashi E, Hirabayashi M, Murakami T. Transgenic rat model of childhood-onset dermatitis by overexpressing telomerase reverse transcriptase (TERT). Transgenic Res., doi:10.?1007/?s11248-016-9939-3, 2016

Koizumi ?O., Hamada S., Minobe S., Hamaguchi-Hamada K.,?Kurumata-Shigeto M., Nakamura M., Namikawa H.?The nerve ring in cnidarians: its presence and structure in hydrozoan?medusae. Zoology?118(2), ?79–88, 2015

Hamada S., Hirashima H., Imaeda M., Okamoto M., Hamaguchi-Hamada K., Kurumata-Shigeto M. Thiamine deficiency induces massive cell death in the olfactory bulbs of mice. J. Neuropathol. Exp. Neurol. 72(12), 1193-1202, 2013

Hasegawa S., Hirabayashi T., Kondo T., Inoue K., Esumi S., Okayama A., Hamada S., Yagi T.,?Constitutively expressed protocadherin-α regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic reion.?Front. Mol. Neurosci.5:97, 2012

Ohsawa S., Hamada S., Kuida K., Yoshida H., Igaki T., Miura M. Maturation of the olfactory sensory neurons by Apaf–1/caspase–9-mediated caspase activity. Proc. Natl. Acad. Sci. USA?107(30), 13366–71, 2010.

Ohsawa S., Hamada S., Asou H., Kuida K., Uchiyama Y., Yoshida H., Miura M. Caspase–9 activation revealed by Semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb. J Neurosci. 29(36), 11385–11392, 2009.

Katori S., Hamada S. (co-first author), Noguchi Y., Fukuda E., Yamamoto T., Yamamoto H., Hasegawa S., Yagi T. Protocadherin-a family is required for serotonergic projections of appropriately innervate target brain areas. J Neurosci. 29(29), 9137–9147, 2009.

Hamaguchi-Hamada K., Fujisawa Y., Koizumi O., Muneoka Y., Okado N., Hamada S. Immunohistochemical evidence for the existence of novel mammalian neuropeptides related to hydra GLW-amide neuropeptide family. Cell Tissue Res. 337(1), 15–25, 2009.

Hattori K., Fukuzako H., Hashiguchi T., Hamada S., Murata Y., Isosaka T., Yuasa S., Yagi T. Decreased expression of Fyn protein and disbalanced alternative splicing patterns in platelets from patients with schizophrenia. Psychiatry Res. 168(2), 119–128, 2009.

Fukuda E., Hamada S., Hasegawa S., Katori S., Sanbo M., Miyakawa T., Yamamoto T., Yamamoto H., Hirabayashi T., Yagi T. Down-regulation of protocadherin-a A isoforms in mice changes contextual fear conditioning and spatial working memory. Eur J Neurosci. 28(7), 1362–1376, 2008.

Ohsawa S., Hamada S., Yoshida H., Miura M. Caspase-mediated changes in histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons. Cell Death & Diff. 15(9), 1429–1439, 2008.

Hasegawa S., Hamada, S.(co-first author), Kumode, Y., Katori, S., Fukuda, E., Uchiyama, Y., Hirabayashi, T., Mombaerts, P., Yagi, T. The protocadherin-a family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse. Mol. Cell Neurosci. 38, 66–79, 2008.

Osada T., Tamamaki N., Song S.Y., Kakazu N., Yamazaki Y., Makino H., Sasaki A., Hirayama T., Hamada S., Nave K.A., Yanagimachi R., Yagi T. Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice. J. Neurosci. 25(37), 8368–8374, 2005.

Esumi S., Kakazu N., Taguchi Y., Hirayama T., Sasaki A., Hirabayashi T., Koide T., Kitsukawa T., Hamada S., Yagi T. Monoallelic yet combinatorial expression of variable exons of the CNR/Protocadherin-a gene cluster in single neurons. Nature Genet. 37(2), 171–176, 2005.

Ohsawa S., Hamada S., Kakinuma Y., Yagi T., Miura M. A novel function of neuronal PAS domain protein 1 (NPAS1) in erythropoietin expression in neuronal cells. J. Neurosci. Res.79(4), 451–458, 2005.

Makino H., Yamazaki Y., Hirabayashi T., Kaneko R., Hamada S., Osada T., Kawamura Y., Yanagimachi R., Yagi T. Mouse embryos and chimera cloned from neural cells in the postnatal cerebral cortex. Cloning Stem Cells 7(1), 44–60, 2005.

Morishita H., Kawaguchi M., Murata Y., Seiwa C., Hamada S., Asou H., Yagi T. Myelination triggers down-regulation of axonal CNR/Protocadherina family expression. Eur. J. Neurosci.20(11), 2843–2847, 2004.

Morishita H., Murata Y., Esumi S., Hamada S., Yagi T. CNR/Pcdhα family in subplate neurons, and developing cortical connectivity. Neuroreport 15(17), 2595–2599, 2004.

Murata Y., Hamada S., Morishita, H., Mutoh T., Yagi T. Interaction with Protocadherin-gamma regulates the cell-surface expression of Protocadherin-alpha. J. Biol. Chem. 279, 49508–49516, 2004.

Hamaguchi-Hamada K., Hamada S., Yagi T. Exposure to hexanal odor induces extraordinary Fos expression in the medial preoptic area and amygdala of Fyn tyrosine kinase-deficient mice.Mol. Brain Res. 130 187–190. 2004.

Hamaguchi-Hamada K., Sanbo C., Hamada S., Yagi T. Exposure to hexanal odor influences maternal behavior and induces neonatal death in Fyn tyrosine kinase-deficient mice. Neurosci. Res. 48(3) 259–67. 2004.

Sugino H., Yanase H., Hamada S., Kurokawa K., Asakawa S., Shimizu N., Yagi T. Distinct genomic sequence of the CNR/Pcdhalpha genes in chicken. Biochem. Biophys. Res. Commun.316(2) 437–45. 2004

MutohT., Hamada S., Senzaki K., Murata Y., Yagi T. Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with β1 integrin mediated through the RGD site of CNR1.Exp. Cell Res. 294(2) 494–508. 2004

Yagi T., Tada M., Tanaka Y., Senzaki K., Hirayama T., Hamada S., Sugino H. Diversity of the cadherin-related neuronal receptor family in the nervous system. Int. Congress Series 1246 127–136. 2002

Yamazaki Y., Makino H., Hamaguchi-Hamada K., Hamada S., Sugino H., Kawase E., Miyata T., Ogawa M., Yanagimachi R., Yagi T. Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer. Proc. Natl. Acad. Sci. USA?98(24) 14022–6. 2001

Hamada S., Yagi T. The cadherin-related neuronal receptor (CNR) family: a novel diversified cadherin family at the synapse. Neurosci. Res. 41(3). 207–215. 2001

Takei Y., Hamada S., Senzaki K., Mutoh T., Sugino H., Yagi T. Two Novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1–8. Genomics 72 321–330. 2001

Maxishima M., Shiga T., Shutoh F., Hamada S., Maeshima T., Okado N.
Serotonin 2A receptor-like immunoreactivity is detected in astrocytes but not in oligodendrocytes of rat spinal cord. Brain Res. 889(1–2). 270–273. 2001

Shutoh F., Hamada S., Shibata M., Narita M., Shiga T., Azmitia E. C., Okado N. Long term depletion of serotonin leads to selective changes in glutamate receptor subunits. Neurosci. Res.?38(4) 365–371. 2000

Sugino H., Hamada S. (co-first author), Yasuda R., Tuji A., Matsuda Y., Fujita M., Yagi T. Genomic organization of the family of CNR cadherin genes in mice and human. Genomics 63(1). 75–87. 2000

Kohmura N., Senzaki K., Hamada S., Kai N., Yasuda R., Watanabe M., Ishii H., Yasuda M., Mishina M., Yagi T. Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron 20. 1137–1151. 1998

Maeshima T., Shutoh F., Hamada S. (corresponding author), Senzaki K., Hamaguchi-Hamada K., Ito R., Okado N. Serotonin2A receptor-like immunoreactivity in rat cerebellar Purkinje cells.Neurosci. Lett. 252(1). 72–74. 1998

Maeshima T., Ito R., Hamada S., Senzaki K., Hamaguchi-Hamada K., Shutoh F., Okado N. The cellular localization of 5-HT2A receptors in the spinal cord and spinal ganglia of the adult rat.Brain Res. 797(1). 118–124. 1998

Hamada S., Senzaki K., Hamaguchi-Hamada K., Tabuchi K., Yamamoto T., Yoshikawa S., Okano H., Okado N. Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. Mol. Brain Res. 54(2). 199–211. 1998

Chen L., Hamaguchi K., Hamada S., Okado N. Regional differences of serotonin-mediated synaptic plasticity in the chicken spinal cord with development and aging. J. Neural Transplant. Plast. 6. 41–48. 1997

Niitsu Y., Hamada S.(co-first author), Hamaguchi K., Mikuni M., Okado N. Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo. Neurosci. Lett. 195. 159–162. 1995

Hamada S., Ogawa M., Okado N. Immunohistochemical examination of intraspinal serotonin neurons and fibers in the chicken lumbar spinal cord and coexistence with leu-enkephalin. Cell Tissue Res. 282. 387–397. 1995

Chen L., Hamaguchi K., Ogawa, M., Hamada S., Okado N. PCPA reduces both monoaminergic afferents and nonmonoaminergic synapses in the cerebral cortex. Neurosci Res. 19. 111–115. 1994

Okado N., Cheng L., Tanatsugu Y., Hamada S., Hamaguchi K. Synaptic loss following removal serotonergic fibers in newly hatched and adult chickens. J Neurobiol. 24. 687–698. 1993

Okado N., Matsukawa M., Noritake S., Ozaki S., Hamada S., Arita M., Kudo N. Species differences in the distribution and coexistence ratio of serotonin and substance P in the monkey, cat, rat and chick spinal cord. Neurosci. Lett. 132(2). 155–158. 1991

2.著書

ラット. 研究者が教える動物飼育 第3巻 ウニ、ナマコから脊椎動物へ, 日本比較生理生化学会編,共立出版:159-164頁,2012

人体の構造と機能および疾病の成り立ち:疾病の成因?病態?診断?治療(分担 執筆担当:9-B,C章) 医歯薬出版 2007

ジーンターゲッティングの最新技術(分担 執筆担当:3-1章 「解剖学的解析法」、132–142) 羊土社 2000

3.日本語総説等

荒木彩 平嶋浩子 車田麻美 濱田俊 チアミン欠乏によって生じる中枢神経障害:Wernicke-Korsakoff症候群 ビタミン 84(11) 510–516. 2010

濱田俊 八木健 プロトカドヘリンとその機能 生化学 78(7) 662–671. 2006

濱田俊 八木健 神経系における多様化膜分子群:遺伝子クラスターを形成するCNR/プロトカドヘリンファミリー 比較生理生化学 20(1). 3–8. 2003

濱田俊 八木健 シナプス形成とカドヘリンスーパーファミリー - 選択的シナプス結合形成の分子基盤か? – 脳21 3(4). 419–426. 2000

岡戸信男、濱田俊 セロトニンニューロンと発生?分化。 実験医学 11(10). 126–132. 1993

濱田俊、浜口香世子、陳玲、岡戸信男  セロトニンの非伝達物質機能:シナップスの形成と維持に果たす役割。 脳と精神の医学 5(1). 87–92. 1994